canSAR.ai
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About
canSAR.ai is a comprehensive, integrated knowledgebase for cancer drug discovery. It combines multidisciplinary data (biology, chemistry, pharmacology, structural biology, cellular networks, clinical annotations) and utilizes machine learning to offer drug-discovery predictions. The platform allows substructure and similarity searches of its chemical database, advanced searches across various data types, and provides access to 3D structures, protein families, and more. canSAR.ai is a free resource, supported by various organizations, and continuously updated with new data.
Platform
Task
Features
• machine learning
• integrated knowledge-base
• advanced search (protein, cell lines, drugs & compounds, diseases, 3d structures, protein families)
• chemical search
• drug discovery predictions
FAQs
What is canSAR?
canSAR.ai is an integrated database that brings together biological, chemical, pharmacological (and eventually clinical) data. Its goal is to integrate this data and make it accessible to cancer research scientists from multiple disciplines, to aid hypothesis generation and decision making towards identifying causes, biomarkers and therapeutics for cancer.
Do I need a license to use canSAR?
No. canSAR.ai is freely available to all cancer researchers, both academic and commercial. Please read the Terms of Use.
Why is canSAR.ai called 'canSAR.ai'?
canSAR is a historical play on words to reflect the fact that it integrates cancer-relevant data with compound Structure-Activity-Relationship (SAR) data. Of course canSAR.ai has grown to be much more than that but the name stuck!
I seem to find that some functionality is missing when using IE
Internet Explorer (IE) is a non-standards compliant browser and has been discontinued my Microsoft. If you want to use the successor of Internet Explorer, we recommend using Microsoft Edge to benefit from the full functionality of canSAR.
How can I inform you of any bugs or problems?
We really appreciate being told about bugs or any other issues you experience while using canSAR. Please email us on cansar@mdanderson.org.
How can I cite canSAR?
canSAR: update to the cancer translational research and drug discovery knowledgebase, Patrizio di Micco, Albert A Antolin, Costas Mitsopoulos, Eloy Villasclaras-Fernandez, Domenico Sanfelice, Daniela Dolciami, Pradeep Ramagiri, Ioan L Mica, Joseph E Tym, Philip W Gingrich, Huabin Hu, Paul Workman, Bissan Al-Lazikani Nucl. Acids Res. 2023 Jan 6;51(D1):D1212-D1219. DOI: 10.1093/nar/gkac1004
Where does the data in canSAR.ai come from?
canSAR.ai data comes from a wide variety of public sources and publications. The internal version of canSAR.ai also includes internally generated experimental data. For latest data sources and statistics, please refer to Data Sources.
How often is the data in canSAR.ai updated?
We try to provide updated data as soon as it it available but generaly on a monthly basis. However, most of the data in canSAR.ai comes from public sources which have different update cycles. The Data Sources page allows you to see the status and content of each update.
How frequently is the 3D structural data updated in canSAR?
We update 3D structures every week, a couple of days after PDB release new structures in order for us to provide additional annotations and integrate this data with the respective chemical and biological information in canSAR.
Do I need to know the official gene name to search for a target?
No, canSAR.ai searches all alternative names, synonyms, descriptions and keywords.
What organisms does canSAR.ai store data on?
canSAR.ai target dictionary focusses on human data, although we have a large number of model organism targets. Target key word searches only search human targets . Chemical screening data is from a wide variety of organisms.
I still cannot find my target and I have searched for different names
Is your target not a human target? Try expanding the search by clicking on "Advanced Search", then choose "All organisms". If you still cannot find your target (this rarely ever happens), and you can obtain the amino acid sequence of your target from another source, try performing a sequence search. If you still cannot find your target, please let us know by emailing cansar@mdanderson.org and we will try our best to help.
I cannot find a compound by searching for its name, but I expect it to be in canSAR
We annotate compound synonyms in canSAR.ai wherever we can. However, to make sure, please do a chemical structure search. If you think data is missing then please contact us on cansar@mdanderson.org.
How do I find out what tissues or cell lines show high expression of my target?
If it is a single target, it is best to view the Target Synopsis and go to the Expression area. There you will find a list of tissues and cell lines with expression levels. See "Target Synopsis" in the Quick Start section for a quick guide on how to do this. If you have multiple targets that you want to know the expression for at once, please use the expression tool (In the tools section)
How do I find out if there is half life or other ADME data for my compound?
This information can be obtained from the "Compound Synopsis" Page for a given compound.
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